GPNMB

Across TCGA patient cohorts, GPNMB RNA expression is significantly associated with the protein abundance of many other proteins, with 16,629 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GPNMB-associated proteins across cancer lineages are ITGAX, SKAP2, and LSP1. Each is linked with GPNMB in more than 8 cancer types. Because this analysis shows association rather than direction, both GPNMB-to-partner and partner-to-GPNMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPNMB versus ITGAX in CCRCC, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPNMB→partner) and Y-score (partner→GPNMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITGAX →	+0.695	+1.302	<.001	<.001	3	9
GBM	SKAP2 →	+0.900	+1.660	<.001	<.001	3	8
BRCA	LSP1 →	+0.606	+1.008	<.001	<.001	3	8
UCEC	APBB1IP →	+0.667	+1.279	<.001	<.001	3	8
UCEC	MYO1F →	+0.574	+1.071	<.001	.001	3	8
OV	ARHGAP25 →	+1.102	+2.109	.002	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,629 associations by consensus.

GPNMB vs ITGAX — CCRCC

Explore this scatter interactively →