GPNMB

Across TCGA pan-cancer cohorts, GPNMB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPNMB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPNMB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPNMB is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where GPNMB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPNMB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+2.287	<.001	12	view →
KIRP	All	All	+2.246	<.001	9	view →
KIRC	Male	All	+1.312	<.001	8	view →
KICH	All	All	+2.639	<.001	7	view →
UCEC	All	All	−1.143	.013	6	view →
BRCA	All	All	−0.415	<.001	4	view →
LIHC	All	II,III,IV	+1.222	.003	3	view →
LUSC	All	All	+1.087	<.001	3	view →
LUAD	All	All	−0.545	.009	3	view →
COAD	All	All	−0.610	.012	2	view →
PRAD	All	All	+0.440	.035	2	view →
READ	Female	All	−2.590	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPNMB–HNSC

Open the HNSC breakdown →