GPHA2

Across TCGA patient cohorts, GPHA2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GPHA2-associated genes across cancer lineages are RNU6-365P, RBPJP7, and LRRC57P1. Each is linked with GPHA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPHA2-to-partner and partner-to-GPHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-365P grouped by GPHA2-low versus GPHA2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPHA2→partner) and Y-score (partner→GPHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-365P →	+0.229	+7.640	<.001	.009	3	1
SKCM	RBPJP7 →	+0.076	+5.097	<.001	.008	3	1
SKCM	LRRC57P1 →	+0.101	+5.362	<.001	.005	3	1
SKCM	ARL2BPP4 →	+0.112	+5.594	<.001	.004	3	1
SKCM	LINC02212 →	+0.029	+5.867	<.001	.003	3	1
SKCM	MTND6P17 →	+0.073	+6.469	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

RNU6-365P by GPHA2 expression — BLCA

Explore this box plot interactively →