GPHA2

Across TCGA pan-cancer cohorts, GPHA2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GPHA2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPHA2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GPHA2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, ACC, and UVM are the cancer types where GPHA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.716	0.570	.002	69	view →
ACC	DFS	Quartile	All	0.192	0.580	<.001	65	view →
UVM	OS	Median	All	0.406	1.000	.001	49	view →
LUAD	DFS	Quartile	All	0.843	0.726	.002	28	view →
UCEC	DFS	Median	All	0.788	0.885	<.001	28	view →
MESO	OS	Tertile	All	0.836	0.366	.012	15	view →
SKCM	DFS	Tertile	III,IV	0.609	0.450	.014	14	view →
LIHC	DFS	Quartile	III,IV	0.198	0.389	.018	10	view →
OV	DFS	Tertile	II,III,IV	0.127	0.198	.016	10	view →
STAD	DFS	Quartile	IV	0.730	0.129	.017	9	view →
THCA	OS	Quartile	II,III,IV	0.897	0.972	.019	9	view →
KIRP	OS	Tertile	III,IV	0.397	0.687	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GPHA2–HNSC (DFS)

Open the HNSC breakdown →