GPC5

Across TCGA patient cohorts, GPC5 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPC5-associated genes across cancer lineages are ASNS, eIF4E, and Tuberin. Each is linked with GPC5 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPC5-to-partner and partner-to-GPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GPC5-low versus GPC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC5→partner) and Y-score (partner→GPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.451	+2.321	<.001	<.001	3	5
UCEC	eIF4E →	+0.210	+2.169	.001	<.001	3	3
UCEC	Tuberin →	+0.255	+1.807	.002	.024	3	3
SKCM	MYH11 →	-0.696	-2.115	.010	.015	3	3
STAD	Rad50 →	-0.241	-2.321	.039	.034	3	2
BLCA	GATA3 →	-0.623	-2.321	.015	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

ASNS by GPC5 expression — UCEC

Explore this box plot interactively →