GPC5

Across TCGA pan-cancer cohorts, GPC5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GPC5 data layer compared with 11 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher GPC5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPC5 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ACC show a favorable association.

UVM, PAAD, and UCEC are the cancer types where GPC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.559	0.871	<.001	138	view →
PAAD	DFS	Quartile	II,III,IV	0.574	0.265	<.001	81	view →
UCEC	OS	Tertile	All	0.582	0.877	<.001	78	view →
ACC	DFS	Quartile	III,IV	0.690	0.070	.006	53	view →
BRCA	OS	Median	All	0.976	0.948	.002	34	view →
GBM	OS	Median	All	0.341	0.489	.002	27	view →
COAD	DFS	Median	IV	0.327	0.633	.006	27	view →
KIRP	DFS	Median	All	0.796	0.909	.003	26	view →
STAD	DFS	Tertile	III,IV	0.549	0.709	.016	24	view →
KICH	OS	Median	III,IV	0.369	0.866	.006	24	view →
KIRC	DFS	Median	All	0.730	0.857	.007	22	view →
ESCA	DFS	Tertile	IV	0.143	0.704	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GPC5–UVM (DFS)

Open the UVM breakdown →