GPC5

Across TCGA pan-cancer cohorts, GPC5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPC5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPC5 RNA is repressed in tumor relative to normal tissue. In most cancer types GPC5 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where GPC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.020	<.001	12	view →
KIRP	Male	All	−3.079	<.001	11	view →
KICH	Male	All	−3.936	<.001	10	view →
LUAD	Male	II,III,IV	−1.990	<.001	9	view →
LUSC	All	III,IV	−1.865	<.001	9	view →
COAD	All	II,III,IV	−0.298	<.001	8	view →
STAD	All	All	−0.185	.001	7	view →
BRCA	All	III,IV	−0.238	<.001	6	view →
LIHC	Female	II,III,IV	+1.050	.004	4	view →
READ	All	All	−0.737	.001	3	view →
CHOL	Female	All	−0.500	.006	2	view →
THCA	All	II,III,IV	−0.365	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPC5–KIRC

Open the KIRC breakdown →