GPC5

Across TCGA cell cohorts, GPC5 mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPC5-associated genes across cancer lineages are OR1M1, OR8B4, and CLLU1-AS1. Each is linked with GPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC5-to-partner and partner-to-GPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1M1 grouped by GPC5-low versus GPC5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC5→partner) and Y-score (partner→GPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1M1 →	+0.016	+3.299	<.001	.003	3	2
LUNG_NSCLC_LUAD	OR8B4 →	+0.019	+3.472	<.001	.004	3	2
URINARY_TRACT	CLLU1-AS1 →	+0.085	+4.087	<.001	.009	3	1
URINARY_TRACT	CFAP97D2 →	+0.032	+4.087	<.001	.009	3	1
SKIN	ZNF705D →	+0.067	+4.196	<.001	.002	3	1
CNS	DACH2 →	+0.423	+3.774	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

OR1M1 by GPC5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →