GPC4

Across TCGA patient cohorts, GPC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,722 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GPC4-associated proteins across cancer lineages are RNASE1, RPL21, and RPL3. Each is linked with GPC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPC4-to-partner and partner-to-GPC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPC4 versus RNASE1 in LUAD, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC4→partner) and Y-score (partner→GPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNASE1 →	+0.660	+1.110	<.001	<.001	3	4
OV	RPL21 →	-0.280	-1.002	.004	.001	2	5
LUAD	RPL3 →	-0.457	-1.099	<.001	<.001	3	4
BRCA	RPL5 →	-0.341	-1.629	<.001	<.001	3	4
LUAD	RPL6 →	-0.442	-0.811	<.001	.001	3	4
BRCA	SBSPON →	+1.119	+1.356	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,722 associations by consensus.

GPC4 vs RNASE1 — LUAD

Explore this scatter interactively →