GPC4

Across TCGA pan-cancer cohorts, GPC4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GPC4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPC4 RNA is repressed in tumor relative to normal tissue. In most cancer types GPC4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where GPC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.059	<.001	8	view →
KICH	All	II,III,IV	−2.658	<.001	7	view →
BRCA	Female	II,III,IV	+0.856	<.001	6	view →
CHOL	All	All	+3.054	<.001	5	view →
COAD	Female	II,III,IV	+0.787	<.001	5	view →
LUSC	All	III,IV	−1.290	.017	4	view →
LUAD	All	IV	−1.224	.005	2	view →
LIHC	Female	All	+0.819	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GPC4–KIRC

Open the KIRC breakdown →