GPC3

Across TCGA patient cohorts, GPC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,878 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GPC3-associated proteins across cancer lineages are SYNPO2_S363, TLN1_S2040, and PPP1R12B. Each is linked with GPC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both GPC3-to-partner and partner-to-GPC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPC3 versus SYNPO2_S363 in HNSC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC3→partner) and Y-score (partner→GPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO2_S363 →	+1.476	+2.202	<.001	<.001	3	7
UCEC	TLN1_S2040 →	+0.920	+1.272	<.001	<.001	3	6
UCEC	PPP1R12B →	+1.028	+1.077	<.001	.005	3	6
UCEC	CORO2B →	+0.887	+1.079	<.001	.003	3	6
BRCA	DPT →	+0.701	+1.249	.001	.002	3	6
UCEC	FBLN5 →	+1.058	+1.260	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,878 associations by consensus.

GPC3 vs SYNPO2_S363 — HNSC

Explore this scatter interactively →