GPC3

Across TCGA pan-cancer cohorts, GPC3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GPC3 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher GPC3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPC3 expression acts as an unfavorable survival marker, although some lineages such as KICH and UCS show a favorable association.

STAD, KIRP, and KICH are the cancer types where GPC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.298	0.546	<.001	94	view →
KIRP	DFS	Quartile	All	0.574	0.858	<.001	89	view →
KICH	OS	Median	III,IV	1.000	0.721	<.001	73	view →
ACC	DFS	Tertile	All	0.252	0.744	<.001	67	view →
UVM	DFS	Tertile	All	0.392	0.900	.002	63	view →
UCS	DFS	Tertile	II,III,IV	0.585	0.127	.001	46	view →
LAML	DFS	Median	All	0.449	0.686	<.001	36	view →
COAD	OS	Quartile	IV	0.316	0.907	.005	31	view →
OV	OS	Median	All	0.367	0.281	.009	28	view →
UCEC	DFS	Quartile	All	0.776	0.891	.006	22	view →
MESO	DFS	Median	III,IV	0.188	0.645	.003	21	view →
LIHC	OS	Median	III,IV	0.533	0.744	.007	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GPC3–STAD (OS)

Open the STAD breakdown →