GPC3

Across TCGA cell cohorts, GPC3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPC3-associated genes across cancer lineages are CRYBB1, ZNF831, and SAXO1. Each is linked with GPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC3-to-partner and partner-to-GPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by GPC3-low versus GPC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC3→partner) and Y-score (partner→GPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRYBB1 →	+0.585	+2.878	.003	.009	3	1
LARGE_INTESTINE	ZNF831 →	+0.014	+3.103	<.001	.004	3	1
LARGE_INTESTINE	SAXO1 →	+0.040	+3.556	.004	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.090	+3.477	.004	.001	3	1
SKIN	SLC4A1 →	+0.293	+3.938	<.001	.005	3	1
OVARY	DEFB125 →	+0.182	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CRYBB1 by GPC3 expression — LARGE_INTESTINE

Explore this box plot interactively →