GPATCH2L

Across TCGA cell cohorts, GPATCH2L mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPATCH2L-associated genes across cancer lineages are FAM25C, HES3, and DEFB133. Each is linked with GPATCH2L in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH2L-to-partner and partner-to-GPATCH2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM25C grouped by GPATCH2L-low versus GPATCH2L-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH2L→partner) and Y-score (partner→GPATCH2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	1
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	1
CNS	DEFB133 →	+0.046	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FAM25C by GPATCH2L expression — BLOOD_Lymphoma

Explore this box plot interactively →