GP2

Across TCGA cell cohorts, GP2 mutation is significantly associated with the RNA expression of many other genes, with 622 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GP2-associated genes across cancer lineages are SPINK9, VN1R2, and OR6B3. Each is linked with GP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GP2-to-partner and partner-to-GP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by GP2-low versus GP2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GP2→partner) and Y-score (partner→GP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.043	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	VN1R2 →	+0.013	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR6B3 →	+0.030	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR5T2 →	+0.009	+4.662	<.001	.005	3	1
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
LARGE_INTESTINE	ZBED4 →	+0.522	+3.137	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 622 associations by consensus.

SPINK9 by GP2 expression — SKIN

Explore this box plot interactively →