GP2

Across TCGA pan-cancer cohorts, GP2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GP2 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher GP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GP2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUSC show a favorable association.

THYM, KIRC, and SARC are the cancer types where GP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	III,IV	0.317	0.913	<.001	65	view →
KIRC	DFS	Quartile	III,IV	0.652	0.822	.004	41	view →
SARC	OS	Quartile	All	0.587	0.819	.002	34	view →
BRCA	OS	Quartile	II,III,IV	0.947	0.873	.006	32	view →
DLBC	OS	Tertile	II,III,IV	0.294	1.000	.013	30	view →
UCS	OS	Quartile	II,III,IV	0.295	0.674	.002	22	view →
KICH	OS	Tertile	II,III,IV	0.479	0.900	.001	22	view →
LGG	OS	Tertile	All	0.694	0.824	.015	21	view →
ACC	OS	Tertile	All	0.640	0.903	.035	21	view →
LUSC	OS	Tertile	III,IV	0.558	0.223	.008	20	view →
LUAD	OS	Tertile	IV	0.237	0.674	.012	16	view →
MESO	OS	Tertile	All	0.777	0.521	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GP2–THYM (DFS)

Open the THYM breakdown →