GON7

Across TCGA patient cohorts, GON7 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GON7-associated genes across cancer lineages are AQP7P2, SNORD82, and RN7SKP230. Each is linked with GON7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GON7-to-partner and partner-to-GON7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P2 grouped by GON7-low versus GON7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GON7→partner) and Y-score (partner→GON7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P2 →	+0.230	+3.232	<.001	<.001	3	1
UCEC	SNORD82 →	+0.636	+3.039	.001	.001	3	1
UCEC	RN7SKP230 →	+0.355	+2.967	.004	.003	3	1
UCEC	OR2J3 →	+0.130	+2.833	<.001	.006	3	1
UCEC	HTN3 →	+0.205	+2.734	<.001	.008	3	1
UCEC	KLRC3 →	+0.214	+2.983	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

AQP7P2 by GON7 expression — UCEC

Explore this box plot interactively →