GOLT1A

Across TCGA patient cohorts, GOLT1A mutation is significantly associated with the RNA expression of many other genes, with 1,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLT1A-associated genes across cancer lineages are NPRL2, LSM10, and NDUFA6. Each is linked with GOLT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLT1A-to-partner and partner-to-GOLT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPRL2 grouped by GOLT1A-low versus GOLT1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLT1A→partner) and Y-score (partner→GOLT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPRL2 →	+0.451	+3.377	.002	.004	3	2
UCEC	LSM10 →	+0.404	+3.584	.005	.003	3	2
UCEC	NDUFA6 →	+0.532	+3.595	.001	.001	3	2
UCEC	LINC01275 →	+0.402	+3.595	<.001	.001	3	2
UCEC	RNU7-59P →	+0.553	+2.370	<.001	.008	3	2
SKCM	HMGN1P31 →	+0.040	+3.990	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,186 associations by consensus.

NPRL2 by GOLT1A expression — UCEC

Explore this box plot interactively →