GOLT1A

Across TCGA pan-cancer cohorts, GOLT1A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GOLT1A data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GOLT1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GOLT1A expression acts as an unfavorable survival marker, although some lineages such as ACC and BLCA show a favorable association.

KIRP, UVM, and ACC are the cancer types where GOLT1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.731	0.915	<.001	138	view →
UVM	DFS	Median	All	0.437	0.765	<.001	109	view →
ACC	OS	Quartile	All	0.967	0.649	.001	80	view →
BLCA	DFS	Quartile	All	0.616	0.419	<.001	67	view →
LUSC	DFS	Tertile	II,III,IV	0.619	0.821	<.001	55	view →
COAD	OS	Median	III,IV	0.678	0.874	.002	29	view →
ESCA	OS	Median	All	0.617	1.000	.009	28	view →
CHOL	DFS	Tertile	II,III,IV	0.190	0.615	.008	28	view →
THCA	OS	Tertile	All	1.000	0.943	.008	24	view →
GBM	OS	Quartile	All	0.372	0.565	.017	17	view →
KIRC	OS	Tertile	All	0.828	0.902	.003	16	view →
LGG	OS	Quartile	All	0.715	0.849	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GOLT1A–KIRP (DFS)

Open the KIRP breakdown →