GOLT1A

Across TCGA pan-cancer cohorts, GOLT1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GOLT1A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GOLT1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GOLT1A is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.

THCA, COAD, and LUSC are the cancer types where GOLT1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GOLT1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	+3.755	<.001	11	view →
COAD	Male	II,III,IV	+1.394	<.001	9	view →
LUSC	Female	II,III,IV	−3.320	<.001	8	view →
BRCA	All	III,IV	+1.439	<.001	8	view →
STAD	All	II,III,IV	+1.826	<.001	6	view →
UCEC	All	All	+1.953	<.001	4	view →
LIHC	All	III,IV	+0.940	.002	4	view →
KIRC	Male	All	−0.702	<.001	4	view →
HNSC	All	All	−0.456	.017	4	view →
READ	Female	All	+1.690	.007	2	view →
KIRP	Male	All	−1.200	.007	2	view →
KIRC	Female	IV	+0.641	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

GOLT1A–THCA

Open the THCA breakdown →