GNRHR

Across TCGA patient cohorts, GNRHR mutation is significantly associated with the RNA expression of many other genes, with 408 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNRHR-associated genes across cancer lineages are RNU7-52P, SPCS2P2, and DHFRP2. Each is linked with GNRHR in more than 1 cancer types. Because this analysis shows association rather than direction, both GNRHR-to-partner and partner-to-GNRHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-52P grouped by GNRHR-low versus GNRHR-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNRHR→partner) and Y-score (partner→GNRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU7-52P →	+0.503	+7.939	<.001	.008	3	2
UCEC	SPCS2P2 →	+0.077	+2.765	<.001	.005	3	2
LUAD	DHFRP2 →	+0.140	+3.379	<.001	.007	3	2
LUAD	NF1P8 →	+0.476	+3.561	<.001	.004	3	2
LUAD	SRSF3P2 →	+0.123	+3.491	<.001	.008	3	2
UCEC	IGLJ5 →	+0.399	+3.200	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 408 associations by consensus.

RNU7-52P by GNRHR expression — PRAD

Explore this box plot interactively →