GNRHR

Across TCGA pan-cancer cohorts, GNRHR RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GNRHR data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GNRHR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GNRHR expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

UVM, UCS, and ESCA are the cancer types where GNRHR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.301	0.779	.002	49	view →
UCS	OS	Median	III,IV	0.618	0.215	.002	38	view →
ESCA	DFS	Tertile	III,IV	0.500	0.276	.007	36	view →
THCA	OS	Median	II,III,IV	0.903	0.984	.001	33	view →
LAML	DFS	Median	All	0.742	0.387	<.001	30	view →
ACC	DFS	Tertile	All	0.207	0.595	.012	22	view →
BLCA	DFS	Quartile	IV	0.303	0.619	<.001	21	view →
LUAD	DFS	Tertile	IV	0.290	0.896	.006	18	view →
HNSC	OS	Median	IV	0.800	0.657	.017	17	view →
CESC	DFS	Median	III,IV	0.226	0.596	.002	12	view →
STAD	OS	Tertile	III,IV	0.578	0.422	.023	12	view →
SKCM	OS	Tertile	III,IV	0.569	0.207	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GNRHR–UVM (OS)

Open the UVM breakdown →