GNGT2

Across TCGA patient cohorts, GNGT2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GNGT2-associated genes across cancer lineages are RNU6-252P, RNU6-511P, and RNU4-37P. Each is linked with GNGT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNGT2-to-partner and partner-to-GNGT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-252P grouped by GNGT2-low versus GNGT2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNGT2→partner) and Y-score (partner→GNGT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-252P →	+0.401	+5.588	<.001	.004	3	2
SKCM	RNU6-511P →	+0.309	+4.771	<.001	.006	3	2
HNSC	RNU4-37P →	+0.878	+7.954	<.001	.008	3	1
UCEC	RN7SL275P →	+0.324	+5.081	<.001	.008	3	1
UCEC	MIR4779 →	+0.915	+5.242	<.001	.007	3	1
LUAD	RNU6-374P →	+0.392	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

RNU6-252P by GNGT2 expression — BLCA

Explore this box plot interactively →