GNGT2

Across TCGA pan-cancer cohorts, GNGT2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GNGT2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GNGT2 RNA is repressed in tumor relative to normal tissue. In most cancer types GNGT2 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where GNGT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNGT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.520	<.001	11	view →
KIRC	Female	All	+0.869	<.001	11	view →
COAD	All	All	−0.517	<.001	10	view →
LUAD	Female	III,IV	−1.142	<.001	9	view →
LUSC	Male	II,III,IV	−1.607	<.001	8	view →
HNSC	All	All	+0.334	.009	7	view →
BRCA	Female	All	+0.158	.022	4	view →
STAD	All	II,III,IV	+0.496	.034	3	view →
PAAD	All	All	−1.472	.043	2	view →
UCEC	All	All	−0.883	<.001	2	view →
THCA	All	II,III,IV	+0.436	.006	2	view →
CHOL	All	All	+0.644	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GNGT2–KICH

Open the KICH breakdown →