GNG5

Across TCGA patient cohorts, GNG5 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG5-associated genes across cancer lineages are RNU6-1082P, RNU6-206P, and RNU6-906P. Each is linked with GNG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG5-to-partner and partner-to-GNG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1082P grouped by GNG5-low versus GNG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG5→partner) and Y-score (partner→GNG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1082P →	+0.610	+4.551	<.001	.009	3	1
UCEC	RNU6-206P →	+0.564	+6.245	<.001	<.001	3	1
UCEC	RNU6-906P →	+0.756	+4.256	<.001	.008	3	1
UCEC	MIR128-1 →	+0.423	+4.937	.002	.005	3	1
UCEC	TRGJP1 →	+1.735	+4.969	<.001	.002	3	1
UCEC	MIR1284 →	+0.463	+4.551	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RNU6-1082P by GNG5 expression — UCEC

Explore this box plot interactively →