GNG5

Across TCGA pan-cancer cohorts, GNG5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GNG5 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GNG5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNG5 expression acts as an unfavorable survival marker, although some lineages such as COAD and THCA show a favorable association.

ACC, COAD, and LIHC are the cancer types where GNG5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.261	0.657	<.001	115	view →
COAD	DFS	Tertile	II,III,IV	0.632	0.385	.001	104	view →
LIHC	OS	Median	All	0.592	0.771	<.001	81	view →
KIRP	DFS	Quartile	All	0.832	0.962	.001	62	view →
LGG	DFS	Median	All	0.624	0.860	<.001	54	view →
THCA	DFS	Tertile	All	0.950	0.861	.002	38	view →
UCEC	DFS	Quartile	All	0.639	0.829	<.001	26	view →
SARC	DFS	Median	All	0.524	0.692	<.001	25	view →
KICH	DFS	Quartile	II,III,IV	0.412	1.000	.010	21	view →
LUAD	OS	Tertile	II,III,IV	0.619	0.840	.016	14	view →
PAAD	OS	Quartile	All	0.317	0.521	.014	14	view →
LUSC	OS	Tertile	II,III,IV	0.601	0.772	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GNG5–ACC (DFS)

Open the ACC breakdown →