GNG4

Across TCGA patient cohorts, GNG4 mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG4-associated genes across cancer lineages are RNA5SP416, RNU4-58P, and SNORA48B. Each is linked with GNG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNG4-to-partner and partner-to-GNG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP416 grouped by GNG4-low versus GNG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG4→partner) and Y-score (partner→GNG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP416 →	+0.785	+2.961	<.001	.002	3	3
BLCA	RNU4-58P →	+0.257	+5.106	.009	.008	3	2
BLCA	SNORA48B →	+0.293	+6.289	<.001	.001	3	2
COAD	LINC02655 →	+0.190	+5.693	<.001	.003	3	2
BLCA	RNA5SP402 →	+0.602	+5.411	<.001	.005	3	2
UCEC	RNA5SP414 →	+0.876	+3.518	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

RNA5SP416 by GNG4 expression — UCEC

Explore this box plot interactively →