GNG3

Across TCGA patient cohorts, GNG3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,455 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNG3-associated proteins across cancer lineages are HIC1_S313, MRTO4_S80, and RPN2. Each is linked with GNG3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GNG3-to-partner and partner-to-GNG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNG3 versus HIC1_S313 in BRCA, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG3→partner) and Y-score (partner→GNG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HIC1_S313 →	-0.575	-0.389	.001	<.001	3	4
PDAC	MRTO4_S80 →	+0.921	+0.478	.006	<.001	3	3
OV	RPN2 →	-0.297	-0.316	<.001	<.001	3	3
LSCC	SAP18 →	+0.248	+0.537	.002	.001	3	3
LSCC	SEC24A →	-0.316	-0.544	<.001	<.001	3	3
LSCC	C1orf35 →	+0.341	+0.406	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,455 associations by consensus.

GNG3 vs HIC1_S313 — BRCA

Explore this scatter interactively →