GNG3

Across TCGA pan-cancer cohorts, GNG3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GNG3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GNG3 RNA is repressed in tumor relative to normal tissue. In most cancer types GNG3 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, BLCA, and HNSC are the cancer types where GNG3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNG3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.431	<.001	10	view →
BLCA	All	All	+0.886	.002	9	view →
HNSC	All	All	+0.187	.003	8	view →
READ	All	All	−1.396	<.001	7	view →
LUSC	All	All	+0.482	<.001	7	view →
BRCA	All	III,IV	+0.605	<.001	6	view →
UCEC	All	All	+0.476	<.001	6	view →
LIHC	Male	All	+0.220	<.001	5	view →
STAD	Female	III,IV	−1.540	.002	3	view →
CHOL	All	All	+0.667	<.001	3	view →
KIRP	All	II,III,IV	+0.342	.032	2	view →
KICH	Female	II,III,IV	+0.347	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GNG3–COAD

Open the COAD breakdown →