GNB3

Across TCGA patient cohorts, GNB3 mutation is significantly associated with the RNA expression of many other genes, with 4,927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB3-associated genes across cancer lineages are SUCLA2P2, GPR148, and SNORA3C. Each is linked with GNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB3-to-partner and partner-to-GNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUCLA2P2 grouped by GNB3-low versus GNB3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB3→partner) and Y-score (partner→GNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SUCLA2P2 →	+0.023	+5.342	<.001	.002	3	2
LUAD	GPR148 →	+0.147	+3.659	<.001	.009	3	2
LUAD	SNORA3C →	+0.219	+4.502	.006	.007	3	2
LUAD	RNU7-12P →	+0.881	+3.855	<.001	.006	3	2
LUAD	RNU6-158P →	+0.451	+4.330	<.001	.002	3	2
LUAD	RN7SL134P →	+0.102	+3.999	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,927 associations by consensus.

SUCLA2P2 by GNB3 expression — CESC

Explore this box plot interactively →