GNAZ

Across TCGA patient cohorts, GNAZ mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAZ-associated genes across cancer lineages are Annexin-1, 4E-BP1_pS65, and 14-3-3_beta. Each is linked with GNAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAZ-to-partner and partner-to-GNAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GNAZ-low versus GNAZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAZ→partner) and Y-score (partner→GNAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.493	+1.505	.006	.034	3	2
SKCM	4E-BP1_pS65 →	+0.268	+2.820	.009	.035	3	1
UCEC	14-3-3_beta →	-0.081	-2.432	.020	.018	3	1
UCEC	eIF4E →	+0.191	+3.472	.008	.002	3	1
UCEC	A-Raf_pS299 →	-0.122	-1.906	.003	.015	3	1
UCEC	FoxM1 →	+0.193	+1.736	.031	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Annexin-1 by GNAZ expression — UCEC

Explore this box plot interactively →