GNAZ

Across TCGA pan-cancer cohorts, GNAZ RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GNAZ’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GNAZ RNA is repressed in tumor relative to normal tissue. In most cancer types GNAZ is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and LIHC are the cancer types where GNAZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNAZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−1.756	<.001	11	view →
KICH	Female	II,III,IV	−1.888	<.001	10	view →
LIHC	Female	II,III,IV	+2.517	<.001	9	view →
KIRC	All	II,III,IV	−0.552	<.001	7	view →
UCEC	All	III,IV	−1.881	<.001	6	view →
LUAD	Female	III,IV	−1.497	<.001	6	view →
BRCA	Female	II,III,IV	−0.883	<.001	6	view →
COAD	Male	All	−0.892	.004	4	view →
CHOL	All	All	+2.846	<.001	3	view →
READ	Female	All	−1.507	.045	2	view →
PRAD	All	All	−1.451	<.001	2	view →
THCA	All	All	+0.324	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GNAZ–BLCA

Open the BLCA breakdown →