GNAZ

Across TCGA pan-cancer cohorts, GNAZ RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GNAZ data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GNAZ RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNAZ expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

UVM, LIHC, and PAAD are the cancer types where GNAZ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.430	0.733	.001	72	view →
LIHC	OS	Tertile	All	0.614	0.796	<.001	64	view →
PAAD	DFS	Median	All	0.486	0.262	.001	39	view →
KICH	DFS	Median	II,III,IV	0.597	1.000	.008	37	view →
ACC	DFS	Median	All	0.517	0.921	<.001	23	view →
LUSC	OS	Median	III,IV	0.444	0.687	.003	22	view →
LAML	DFS	Median	All	0.267	0.493	.001	22	view →
SKCM	OS	Quartile	IV	0.807	0.265	.009	18	view →
UCEC	DFS	Quartile	All	0.761	0.880	.004	18	view →
KIRP	DFS	Tertile	IV	0.363	0.673	.010	15	view →
HNSC	OS	Median	All	0.620	0.792	.003	14	view →
UCS	DFS	Tertile	IV	0.500	0.981	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GNAZ–UVM (DFS)

Open the UVM breakdown →