GNAZ

Across TCGA cell cohorts, GNAZ mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNAZ-associated genes across cancer lineages are TFAP2E, AUNIP, and TTI2. Each is linked with GNAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAZ-to-partner and partner-to-GNAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFAP2E grouped by GNAZ-low versus GNAZ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAZ→partner) and Y-score (partner→GNAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFAP2E →	+1.610	+3.064	<.001	.009	3	1
LARGE_INTESTINE	AUNIP →	+0.564	+3.064	.004	.009	3	1
LARGE_INTESTINE	TTI2 →	+0.700	+3.137	.002	.007	3	1
LARGE_INTESTINE	INTS12 →	+0.464	+3.064	.005	.009	3	1
LARGE_INTESTINE	ADAM21 →	+0.572	+3.064	<.001	.009	3	1
LARGE_INTESTINE	CX3CR1 →	+0.138	+3.215	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

TFAP2E by GNAZ expression — LARGE_INTESTINE

Explore this box plot interactively →