GNAI2

Across TCGA cell cohorts, GNAI2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GNAI2-associated genes across cancer lineages are KRTAP9-1, ELOA3DP, and TARM1. Each is linked with GNAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAI2-to-partner and partner-to-GNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-1 grouped by GNAI2-low versus GNAI2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI2→partner) and Y-score (partner→GNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KRTAP9-1 →	+0.083	+5.169	<.001	.004	3	2
LARGE_INTESTINE	ELOA3DP →	+0.026	+3.103	<.001	.004	3	2
BONE	TARM1 →	+0.026	+5.169	<.001	.004	3	1
BLOOD_Lymphoma	FSHB →	+0.007	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	NKX6-3 →	+1.150	+3.491	.002	.008	3	1
BLOOD_Lymphoma	CEACAM3 →	+0.078	+3.757	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

KRTAP9-1 by GNAI2 expression — BONE

Explore this box plot interactively →