GNAI2

Across TCGA pan-cancer cohorts, GNAI2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GNAI2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GNAI2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GNAI2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where GNAI2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNAI2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.992	<.001	12	view →
KIRC	Female	All	+0.928	<.001	11	view →
KICH	Male	All	−1.510	<.001	8	view →
LUSC	Female	II,III,IV	−0.967	<.001	8	view →
LUAD	Female	All	−0.719	<.001	8	view →
LIHC	Female	II,III,IV	+0.690	<.001	8	view →
UCEC	All	All	−0.758	<.001	6	view →
COAD	Female	All	+0.489	.004	5	view →
CHOL	All	All	+0.878	.018	4	view →
STAD	All	II,III,IV	+0.564	.014	4	view →
THCA	All	All	+0.228	.001	4	view →
BRCA	All	All	−0.154	.035	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GNAI2–HNSC

Open the HNSC breakdown →