GNA14

Across TCGA patient cohorts, GNA14 mutation is significantly associated with the RNA expression of many other genes, with 1,335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA14-associated genes across cancer lineages are RNU6-996P, MUC20, and RN7SL447P. Each is linked with GNA14 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNA14-to-partner and partner-to-GNA14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-996P grouped by GNA14-low versus GNA14-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA14→partner) and Y-score (partner→GNA14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-996P →	+0.265	+8.057	<.001	.005	3	3
UCEC	MUC20 →	-0.866	-2.305	.003	.006	3	2
BRCA	RN7SL447P →	+0.201	+5.926	<.001	.002	3	2
UCEC	SNX3P1Y →	+0.065	+3.834	<.001	.007	3	2
UCEC	STING1 →	-0.705	-2.512	<.001	<.001	3	2
UCEC	FAM43A →	-0.743	-3.071	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,335 associations by consensus.

RNU6-996P by GNA14 expression — BRCA

Explore this box plot interactively →