GNA14

Across TCGA pan-cancer cohorts, GNA14 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GNA14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GNA14 RNA is repressed in tumor relative to normal tissue. In most cancer types GNA14 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where GNA14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNA14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	−0.933	<.001	12	view →
KIRP	Female	II,III,IV	−2.567	<.001	11	view →
KICH	Male	All	−2.409	<.001	11	view →
THCA	All	IV	−3.567	<.001	10	view →
LUSC	Female	II,III,IV	−2.744	<.001	9	view →
HNSC	Male	IV	−1.371	<.001	8	view →
LIHC	All	III,IV	−1.241	<.001	8	view →
BLCA	Male	III,IV	−2.087	<.001	7	view →
UCEC	All	All	−2.666	<.001	6	view →
PRAD	All	All	−0.524	<.001	2	view →
CHOL	All	All	−0.605	.034	1	view →
LUAD	All	All	−0.391	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GNA14–KIRC

Open the KIRC breakdown →