GNA12

Across TCGA cell cohorts, GNA12 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNA12-associated genes across cancer lineages are KCNG4, OR12D3, and DEFA6. Each is linked with GNA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA12-to-partner and partner-to-GNA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNG4 grouped by GNA12-low versus GNA12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA12→partner) and Y-score (partner→GNA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNG4 →	+0.006	+5.539	.001	.003	3	1
OVARY	OR12D3 →	+0.016	+5.807	<.001	.001	3	1
OVARY	DEFA6 →	+0.111	+5.196	.004	.005	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	OR2V2 →	+0.020	+4.095	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KCNG4 by GNA12 expression — BLOOD_Leukemia

Explore this box plot interactively →