GNA12

Across TCGA pan-cancer cohorts, GNA12 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GNA12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GNA12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GNA12 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where GNA12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNA12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.520	<.001	12	view →
KIRC	All	All	+0.406	<.001	11	view →
LIHC	Female	II,III,IV	+1.369	<.001	9	view →
LUAD	All	II,III,IV	+0.513	<.001	9	view →
COAD	Female	All	+0.425	<.001	6	view →
THCA	All	All	−0.297	<.001	6	view →
CHOL	All	All	+2.103	<.001	5	view →
STAD	Male	II,III,IV	+1.086	.003	5	view →
LUSC	Male	All	+0.491	<.001	4	view →
KICH	Female	All	−0.568	.002	3	view →
KIRP	All	All	+0.346	.018	3	view →
BLCA	Male	IV	−1.367	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GNA12–HNSC

Open the HNSC breakdown →