GMNN

Across TCGA patient cohorts, GMNN mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMNN-associated genes across cancer lineages are eEF2, GAPDH, and Lck. Each is linked with GMNN in more than 1 cancer types. Because this analysis shows association rather than direction, both GMNN-to-partner and partner-to-GMNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GMNN-low versus GMNN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMNN→partner) and Y-score (partner→GMNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.526	+3.000	.005	.036	3	1
UCEC	GAPDH →	+0.697	+2.999	.013	.035	3	1
UCEC	Lck →	+0.247	+3.321	.018	.010	3	1
UCEC	mTOR_pS2448 →	-0.226	-3.321	.003	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.245	+2.183	.023	.035	3	1
UCEC	Akt →	-0.269	-3.159	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by GMNN expression — UCEC

Explore this box plot interactively →