GLI2

Across TCGA cell cohorts, GLI2 mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GLI2-associated genes across cancer lineages are EAF1, FABP12, and ZNF330. Each is linked with GLI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLI2-to-partner and partner-to-GLI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EAF1 grouped by GLI2-low versus GLI2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI2→partner) and Y-score (partner→GLI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EAF1 →	+0.535	+3.376	<.001	.002	3	3
CNS	FABP12 →	+0.120	+3.566	<.001	.003	3	3
LARGE_INTESTINE	ZNF330 →	+0.395	+2.652	.008	.001	3	2
LARGE_INTESTINE	STXBP3 →	+0.477	+2.526	<.001	.002	3	2
LARGE_INTESTINE	PRPSAP2 →	+0.470	+2.386	.008	.007	3	2
LARGE_INTESTINE	SLC25A33 →	+0.445	+1.941	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

EAF1 by GLI2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →