GLI2

Across TCGA pan-cancer cohorts, GLI2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GLI2 data layer compared with 12 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GLI2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GLI2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

KIRP, UVM, and LUAD are the cancer types where GLI2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.586	0.773	<.001	156	view →
UVM	DFS	Median	All	0.397	0.755	<.001	135	view →
LUAD	DFS	Quartile	All	0.494	0.658	.003	104	view →
BLCA	OS	Quartile	All	0.349	0.648	<.001	88	view →
ACC	DFS	Tertile	All	0.162	0.620	<.001	73	view →
LGG	DFS	Median	All	0.297	0.511	<.001	54	view →
THCA	OS	Median	II,III,IV	0.795	1.000	.003	35	view →
BRCA	OS	Tertile	III,IV	0.886	0.746	.003	24	view →
KIRC	DFS	Tertile	II,III,IV	0.440	0.610	.014	23	view →
KICH	OS	Tertile	All	0.689	1.000	.011	22	view →
UCEC	OS	Tertile	All	0.664	0.789	.003	22	view →
ESCA	OS	Median	All	0.581	0.395	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GLI2–KIRP (OS)

Open the KIRP breakdown →