GLI1

Across TCGA patient cohorts, GLI1 mutation is significantly associated with the RNA expression of many other genes, with 4,795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLI1-associated genes across cancer lineages are TUBA1C, DCPS, and TRAF3. Each is linked with GLI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GLI1-to-partner and partner-to-GLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBA1C grouped by GLI1-low versus GLI1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI1→partner) and Y-score (partner→GLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TUBA1C →	+0.579	+3.485	.003	.002	3	4
UCEC	DCPS →	+0.416	+1.711	.001	.001	3	3
LUSC	TRAF3 →	+0.424	+2.333	.008	.003	3	3
UCEC	PAXIP1 →	+0.428	+1.947	<.001	<.001	3	3
UCEC	FOXM1 →	+0.747	+1.968	<.001	<.001	3	3
UCEC	SKA1 →	+0.713	+1.958	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,795 associations by consensus.

TUBA1C by GLI1 expression — LUAD

Explore this box plot interactively →