GLI1

Across TCGA patient cohorts, GLI1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLI1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and E-Cadherin. Each is linked with GLI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLI1-to-partner and partner-to-GLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GLI1-low versus GLI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI1→partner) and Y-score (partner→GLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.555	-2.263	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.050	+2.330	.003	.020	3	3
COAD	E-Cadherin →	-0.797	-3.450	.005	.005	3	3
UCEC	JNK2 →	+0.251	+1.938	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.127	-2.209	.009	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.341	-1.502	.021	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by GLI1 expression — UCEC

Explore this box plot interactively →