GLI1

Across TCGA cell cohorts, GLI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,855 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GLI1-associated GO terms across cancer lineages are Positive regulation of termination of RNA polymerase II transcription, Positive regulation of termination of DNA-templated transcription, and Microtubule polymerization. Each is linked with GLI1 in more than 8 cancer types. Because this analysis shows association rather than direction, both GLI1-to-partner and partner-to-GLI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of termination of RNA polymerase II transcription grouped by GLI1-low versus GLI1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI1→partner) and Y-score (partner→GLI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of termination of RNA polymerase II transcription →	+0.145	+1.694	.001	.007	3	9
OVARY	Positive regulation of termination of DNA-templated transcription →	+0.145	+1.694	.001	.007	3	9
BLOOD_Leukemia	Microtubule polymerization →	+0.075	+0.574	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.102	+1.324	<.001	.003	3	8
OESOPHAGUS	Positive regulation of cytoplasmic translational initiation →	+0.215	+1.821	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Protein localization to ciliary membrane →	+0.107	+1.727	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,855 associations by consensus.

Positive regulation of termination of RNA polymerase II transcription by GLI1 expression — OVARY

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