Across TCGA patient cohorts, GK mutation is significantly associated with the RNA expression of many other genes, with 2,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GK-associated genes across cancer lineages are MTND6P9, CYCSP22, and LINC02127. Each is linked with GK in more than 1 cancer types. Because this analysis shows association rather than direction, both GK-to-partner and partner-to-GK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GK→partner) and Y-score (partner→GK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTND6P9 →	+0.091	+4.497	<.001	.009	3	2
BLCA	CYCSP22 →	+0.114	+5.147	<.001	.003	3	2
BLCA	LINC02127 →	+0.426	+4.899	.008	.005	3	2
BLCA	CA15P2 →	+0.029	+4.899	.001	.005	3	2
SKCM	RN7SL248P →	+0.081	+5.748	<.001	<.001	3	2
UCEC	BAG3 →	+0.416	+2.058	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,685 associations by consensus.

Exploration

GK survival (RNA) · tumor vs normal (RNA) · all GK data types