Across TCGA pan-cancer cohorts, GK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GK’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GK RNA is repressed in tumor relative to normal tissue. In most cancer types GK is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.
KIRP, THCA, and KIRC are the cancer types where GK tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GK RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.