GHR

Across TCGA patient cohorts, GHR mutation is significantly associated with the RNA expression of many other genes, with 2,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHR-associated genes across cancer lineages are EIF1, CCDC43, and SKA2. Each is linked with GHR in more than 2 cancer types. Because this analysis shows association rather than direction, both GHR-to-partner and partner-to-GHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF1 grouped by GHR-low versus GHR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHR→partner) and Y-score (partner→GHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EIF1 →	+0.215	+1.031	.001	.008	3	3
UCEC	CCDC43 →	+0.484	+2.523	<.001	<.001	3	3
SKCM	SKA2 →	+0.340	+1.128	.005	.003	3	3
LUAD	TUBG1 →	+0.672	+3.459	.001	.005	3	3
LUAD	FN3KRP →	+0.568	+3.471	<.001	.002	3	3
UCEC	PSMC3IP →	+0.505	+2.608	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,578 associations by consensus.

EIF1 by GHR expression — SKCM

Explore this box plot interactively →