GHR

Across TCGA pan-cancer cohorts, GHR RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GHR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GHR RNA is repressed in tumor relative to normal tissue. In most cancer types GHR is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and LUAD are the cancer types where GHR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GHR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.270	<.001	11	view →
KIRP	Male	All	−1.947	<.001	11	view →
LUAD	Female	III,IV	−1.872	<.001	11	view →
COAD	All	IV	−1.700	<.001	11	view →
LIHC	Male	II,III,IV	−2.400	<.001	9	view →
STAD	All	All	−1.489	<.001	9	view →
BLCA	Male	IV	−2.692	<.001	8	view →
READ	Female	All	−2.854	<.001	7	view →
BRCA	All	All	−2.425	<.001	6	view →
UCEC	All	All	−2.073	<.001	6	view →
KIRC	Male	All	−0.583	.001	6	view →
KICH	All	All	−1.078	.004	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GHR–THCA

Open the THCA breakdown →